Plenhyage XL Medium Advanced Polynucleotide Skin Regeneration Treatment
Plenhyage XL Medium is an injectable regenerative treatment formulated with 2% high-molecular-weight polymerised polynucleotides (20 mg/ml) derived from highly purified salmon DNA. Designed to support the skin’s natural regenerative processes, Plenhyage XL Medium helps improve hydration, elasticity, firmness and overall skin quality.
Unlike conventional dermal fillers, Plenhyage XL Medium is designed to support skin regeneration and tissue remodelling rather than provide permanent volumising effects. Its polynucleotide-based formulation helps create an optimal environment for fibroblast activity, supporting the skin’s natural renewal processes and contributing to improved tissue quality.
Key Benefits
- Supports skin regeneration by encouraging natural cellular repair and renewal
- Improves skin hydration through the hydrophilic properties of polynucleotides
- Enhances elasticity and firmness by supporting healthier dermal tissue
- Supports fibroblast activity and the natural production of collagen and elastin
- Helps improve skin texture and density for a smoother, more revitalised appearance
- Supports photoaged and ageing skin affected by environmental and oxidative stress
- Provides antioxidant activity, helping to counteract hydroxyl free radicals
- Biocompatible and resorbable formulation designed for professional aesthetic use
Suitable Treatment Areas
Plenhyage XL Medium is indicated for professional treatment of:
- Face
- Neck
- Décolleté
Its medium concentration makes it particularly suited to skin requiring revitalisation, improved hydration and enhanced elasticity where a regenerative approach is preferred.
How Plenhyage XL Medium Works
The high-molecular-weight polymerised polynucleotides in Plenhyage XL Medium have strong water-binding properties, helping support tissue hydration and skin firmness. The formulation is designed to promote an environment conducive to fibroblast activity and cellular turnover, helping restore elasticity and improve the overall condition of the skin.
With continued skin remodelling, the treatment can contribute to improvements in skin quality, hydration, firmness, elasticity and texture, making it suitable for clients seeking natural-looking regenerative results rather than traditional volumisation.
Product Specifications
| Specification | Details |
|---|---|
| Product | Plenhyage XL Medium |
| Active Ingredient | High-molecular-weight polymerised polynucleotides |
| Concentration | 2% / 20 mg/ml |
| Source | Highly purified salmon-derived DNA |
| Volume | 2 ml |
| Presentation | 1 pre-filled glass syringe |
| Needles | 2 disposable needles |
| Treatment Areas | Face, neck and décolleté |
| Product Type | Injectable regenerative medical device |
| Regulatory Status | Class III Medical Device, CE 0373 |
| Use | Professional medical use only |
Professional Use Only
Plenhyage XL Medium is a Class III CE 0373 medical device intended for professional medical use and is not intended for sale or administration to private individuals. Treatment should only be performed by appropriately qualified healthcare or aesthetic professionals in accordance with the manufacturer’s instructions for use.
Plenhyage XL Medium is an advanced polynucleotide solution for professionals seeking to support skin regeneration, hydration, elasticity and overall dermal quality through a regenerative approach.



