Plenhyage XL Strong High-Concentration Polynucleotide Skin Regeneration Treatment
Plenhyage XL Strong is an advanced injectable regenerative treatment containing 2.5% high-molecular-weight polymerised polynucleotides (25 mg/ml). Developed by Bioformula, Plenhyage XL Strong uses highly purified salmon-derived DNA to support the skin’s natural regenerative processes and improve overall tissue quality.
With a higher polynucleotide concentration than Plenhyage XL Medium, the Strong formulation is designed for more intensive skin regeneration, particularly where there are concerns surrounding reduced elasticity, firmness, skin density, photoageing and more pronounced tissue changes.
Plenhyage XL Strong is not a conventional hyaluronic acid dermal filler. Its purpose is to support biological skin regeneration, hydration, fibroblast activity and tissue remodelling rather than create artificial volume.
Key Benefits
- Supports biological skin regeneration and tissue revitalisation
- Helps improve skin elasticity and firmness
- Provides intensive hydration to support healthier-looking skin
- Supports fibroblast activity, creating favourable conditions for tissue regeneration
- Helps promote cellular turnover and skin remodelling
- Supports improvements in skin density and overall skin quality
- Helps address signs of ageing and photoageing
- Provides antioxidant activity to help protect against free-radical damage
- Suitable for skin affected by reduced elasticity, dehydration and tissue quality concerns
- Biocompatible and resorbable polynucleotide formulation
Suitable Treatment Areas
According to the manufacturer, Plenhyage XL Strong can be used professionally on:
- Face
- Neck
- Décolleté
- Body
The product is particularly suited to areas where more intensive regenerative treatment is required, including skin showing reduced elasticity, signs of photoageing or changes in tissue quality.
How Plenhyage XL Strong Works
Plenhyage XL Strong contains high-molecular-weight polymerised polynucleotides. These molecules have hydrating and antioxidant properties and are designed to create a favourable environment for fibroblast activity. By supporting the skin’s natural regenerative processes, Plenhyage XL Strong can help improve hydration, elasticity and tissue quality while supporting cellular turnover and dermal remodelling.
Product Specifications
| Specification | Details |
|---|---|
| Product Name | Plenhyage XL Strong |
| Manufacturer | Bioformula, Italy |
| Active Ingredient | High-molecular-weight polymerised polynucleotides |
| Concentration | 2.5% / 25 mg/ml |
| Source | Highly purified salmon-derived DNA |
| Volume | 2 ml |
| Presentation | 1 pre-filled glass syringe |
| Needles | 2 disposable needles |
| Recommended Areas | Face, neck, décolleté and body |
| Product Type | Injectable regenerative medical device |
| Regulatory Status | Class III Medical Device, CE 0373 |
| Intended Use | Professional medical use only |
Professional Use Only
Plenhyage XL Strong is a Class III CE 0373 medical device intended for professional medical use and is not intended for sale to private individuals. Administration should only be undertaken by an appropriately qualified medical professional in accordance with the manufacturer’s instructions for use and applicable regulations.



